Progressive Development of Aberrant Smooth Muscle Cell Phenotype in Abdominal Aortic Aneurysm Disease
نویسندگان
چکیده
منابع مشابه
Characterizing Aortic Smooth Muscle Cell Phenotype in the Setting of Thoracic Aortic Aneurysm
INTRODUCTION Bicuspid aortic valve disease (BAV) is the most common congenital cardiac malformation occurring in 1-2% of the general population [1] [2]. Normally, the aortic valve is separated into 3 valves. However, BAV involves fusing of the valvular leaflets during development, resulting in a 2-valve structure instead of the normal 3-valve structure. BAV predisposes patients to a thoracic ao...
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Dear Editor,Abdominal aortic aneurysm is often asymptomatic, less recognized, and causes considerable mortality and morbidity, if missed. The incidence varies from country to country and the occurrence is influenced by modifiable (smoking, coronary heart disease, hypertension, dyslipidemia, and prolonged steroid therapy) and non-modifiable risk factors (increasing age, male gender, and positive...
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AIMS Dissection and rupture of the ascending aorta are life-threatening conditions resulting in 80% mortality. Ascending aortic replacement in patients presenting with thoracic aortic aneurysm (TAA) is determined by metric measurement. However, a significant number of dissections occur outside of the parameters suggested by the current guidelines. We investigate the correlation among altered ha...
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The causality of the associations between cellular and mechanical mechanisms of abdominal aortic aneurysm (AAA) formation has not been completely defined. Because reactive oxygen species are established mediators of AAA growth and remodeling, our objective was to investigate oxidative stress-induced alterations in aortic biomechanics and microstructure during subclinical AAA development. We inv...
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OBJECTIVE to examine the expression of transforming growth factor beta1 (TGF-beta1) and the cell kinetics of smooth muscle cells (SMCs) at the neck of abdominal aortic aneurysms (AAAs). MATERIALS AND METHODS expression of alpha-smooth muscle actin and TGF-beta1 was evaluated by immunostaining, and cell kinetics were estimated by terminal deoxynucleotidyl transferase-mediated dUTP-biotin nick ...
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ژورنال
عنوان ژورنال: Journal of Vascular Research
سال: 2017
ISSN: 1018-1172,1423-0135
DOI: 10.1159/000484088